Traducción del artículo originalmente publicado como Sorgner, S. L. (2017). Immortality as Utopia and the Relevance of Nihilism. En Y. Tuncel (ed), Nietzsche and transhumanism. Precursor or enemy? (pp. 248-261). Cambridge Scholars Publishing. Este texto ha sido Publicado con la autorización de Cambridge Scholars Publishing. Agradecemos a Stefan Lorenz Sorgner por autorizarnos a realizar la traducción de este texto.

Se trata de captar la evolución del concepto de hombre y de tecnología desde la perspectiva de Martín Heidegger, desde los parámetros presentados en la pregunta por el ser y la pregunta por la técnica a lo largo de su obra. Se revisan las nuevas concepciones sobre el mundo y se plantea una visión crítica sobre la relación sujetoobjeto; para ello se intenta clarificar los conceptos de Dasein y Gestell, como puntos vitales desde donde se puede emprender dicha indagación. .

The purpose is to show the phenomenon of the “Decolonization” starting from the Heideggerian concept of “destruction” of the Metaphysical language which would have a similar sense to the notion of “De-construction” that comes up from the same conception of the Heideggerian destruction. The Heideggerian proposal has guidelines to begin to “to destroy”, “ to de-construct” the imperatives of thought imposed during the colonization of Latin America and likewise, opens other ways to think “post”, in this case, “post-colonial” or a (...) “De-colonization” of thought, according to my thesis. Therefore, “estar” (to be) is proposed as a concept to destroy the Metaphysical postulates and imperatives imposed in the colony and also, to show the own language of the Latin American thought. It is necessary to emphasize that the theoretical‐philosophical basis is not evident in the development of the post-modern and post-colonial thesis and debates in Latin America, since these speeches are exclusively pronounced from the literary field. Thus, the philosophical basis is necessary, otherwise, it would not be possible to perceive completely the phenomenon neither the problem. (shrink)

Introduction: Congenital myasthenic syndromes refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild symptoms to life-limiting forms with neonatal onset. Long-term follow-up studies on disease progression and treatment-response in pediatric patients are rare.Patients and Methods: We analyzed retrospective clinical and medication data in a cohort of 32 CMS-patients including the application of a standardized, not yet validated test to examine muscular strength and endurance in 21 patients at the (...) last follow-up. Findings obtained in our cohort were compared with long-term follow-up studies of CMS-cohorts from the literature by considering the underlying molecular mechanisms. Outcomes of CMS-ST were compared to results of normal clinical assessment.Results: Thirty-two pediatric patients with defects in eight different CMS-genes were followed by a median time of 12.8 years. Fifty-nine percentage of patients manifested with first symptoms as neonates, 35% as infants. While 53% of patients presented a reduced walking distance, 34% were wheelchair-bound. Even under adequate therapy with pyridostigmine and 3,4-diaminopyridine, CHAT-mutations led to the progression of muscular weakness partly in combination with persistent respiratory and bulbar symptoms. RAPSN, CHRND, and CHRNB1 patients with neonatal manifestation, early respiratory problems, and bulbar symptoms showed a good and maintained treatment response. CHAT and CHRNE patients required higher PS dosages, whereas RAPSN patients needed a lower mean dosage at the last follow-up. The benefits of short-term medication and long-term progression of symptoms were highly dependent on the specific genetic defect. CMS-ST was carried out in 17/21 patients, determined affected muscle groups including bulbar and ocular symptoms, some of which were not reported by the patients.Conclusions: Our findings and comparison with the literature- suggest a better treatment-response and less severe progression of symptoms present in patients suffering from mutations in CMS-genes directly associated with receptor deficiency, while patients with defects leading to synaptopathy and presynaptic defects tend to have worse outcomes. Assessment of affected muscular groups and clinical symptoms by CMS-ST may be a useful tool for optimal therapeutic management of the patients, especially for future clinical studies. (shrink)

The aim of this paper is to provide a theoretical and formal framework to understand how the proprioceptive and kinesthetic system learns about body position and possibilities for movement in ongoing action and interaction. Whereas most weak embodiment accounts of proprioception focus on positionalist descriptions or on its role as a source of parameters for internal motor control, we argue that these aspects are insufficient to understand how proprioception is integrated into an active organized system in continuous and dynamic interaction (...) with the environment. Our strong embodiment thesis is that one of the main theoretical principles to understand proprioception, as a perceptual experience within concrete situations, is the coupling with kinesthesia and its relational constitution—self, ecological, and social. In our view, these aspects are underdeveloped in current accounts, and an enactive sensorimotor theory enriched with phenomenological descriptions may provide an alternative path toward explaining this skilled experience. Following O'Regan and Noë sensorimotor contingencies conceptualization, we introduce three distinct notions of proprioceptive kinesthetic-sensorimotor contingencies, which we describe conceptually and formally considering three varieties of perceptual experience in action: PK-SMCs-self, PK-SMCs-self-environment, and PK-SMC-self-other. As a proof of concept of our proposal, we developed a minimal PK model to discuss these elements in detail and show their explanatory value as important guides to understand the proprioceptive/kinesthetic system. Finally, we also highlight that there is an opportunity to develop enactive sensorimotor theory in new directions, creating a bridge between the varieties of experiences of oneself and learning skills. (shrink)

Secondo un programma di ricerca inaugurato da Darwin e oggi sempre più popolare, gli aspetti fondamentali della nostra psicologia morale sono il prodotto della selezione naturale. Le nostre convinzioni morali, così come la nostra tendenza a comportarci in accordo con queste convinzioni, sarebbero il risultato di processi analoghi a quelli che hanno prodotto il collo delle giraffe e le ali degli uccelli: la ragione per cui siamo convinti di dover tener fede alla parola data è che questa credenza (...) è stata adattiva per i nostri antenati, che ce l'hanno trasmessa. Il libro introduce i lettori a questo affascinante ambito di ricerca, spaziando dalla teoria dei giochi evolutiva alla selezione parentale e alla selezione di gruppo, per poi passare a discutere le conseguenze di tali risultati per la questione della natura della morale, sostenendo che se la nostra psicologia morale è davvero il prodotto della selezione naturale allora dovremmo abbandonare l'idea che esistano norme morali oggettive. (shrink)

Thirteenth-century debates on time are frequently reduced to the opposition between an Ancient tradition, embodied by Augustine, and the Aristotelian philosophy as “physicalist” reading of the problem. However, before the diffusion of the Latin translation of Aristotle’s Physics, notions such as ‘time’, ‘eternity’, ‘aevum’, and ‘present’ have a rich range of meanings and nuances which cannot be considered a mere repetition of an ‘Augustinian model’. A systematic analysis of selected passages of Marius Victorinus’ Explanationes in Ciceronis Rhetoricam provides a representative (...) example of this complexity, making available new conceptual material to reconstruct the sources of the medieval discussions about time and durations. (shrink)

The notion of human dignity stands at the core of contemporary debates on rights, politics, and ethics. Many scholars consider the Renaissance discourse on dignity as one of its main contributions to the transition from the Middle Ages to modernity. This article examines the role of human dignity in the philosophies of Marsilio Ficino and Giovanni Pico della Mirandola. In their works human dignity relates both to freedom and to a Neo-Platonic ontology, which raises the question of how they (...) reconcile these two possibly contradictory elements. I show that starting from the insight that human beings are “naturally” free and able to make right choices, Ficino and Pico argue that human dignity consists in the ability of humans to understand what is good and to act accordingly. I thus defend the thesis that their conception of human dignity is not modern because it liberates human beings from the “history of being” but rather because it paves the way for their liberation to become rational beings. (shrink)

Anche se siamo comunemente abituati a pensare alla scienza come a un qualcosa di assolutamente atemporale e indipendente da tutto, in realtà essa è profondamente influenzata dalla cultura e dalla società del tempo in cui vive. Infatti né la scienza è isolabile dalla società, né la società è isolabile dalla scienza, tanto meno come si sta configurando oggi. Per approfondire questi aspetti, esistono però due visioni antagoniste che bisogna superare: secondo la visione scolastica, retaggio del positivismo ottocentesco ancora molto diffuso (...) fra scienziati e pubblico di non esperti, la scienza è conoscenza senza soggetto conoscente. All'opposto, la visione cinica della scienza, sull'onda di talune elaborazioni della sociologia della scienza, la riduce a nient'altro che a una costruzione di soggetti che partecipano al gioco scientifico, una cultura come altre e da "mediare", e comunque una conoscenza relativa, se non frutto di una costruzione puramente soggettiva, arbitraria, ideologica. Un'analisi della costituzione sociale della scienza può, invece, mirare a un'indagine scientifica sulla scienza proprio configurando una relatività della conoscenza che supera sia l'assolutismo idealistico sia il relativismo soggettivistico. (shrink)